One of the incidents I referred to as a failure of science - the misapprehension of the safety of Vioxx - may be linked to Vioxx researchers throwing out data under institutional p-hacking type guidelines:
http://bigthink.com/neurobonkers/the-sta...of-science
"We then hear of a real case study concerning Merck’s Vioxx painkiller marketed in over eighty countries with a peak value of over two and a half billion. After a patient died of a heart attack it emerged in court proceedings that Merck had allegedly omitted from their research findings published in the Annals of Internal Medicine that five of the patients who participated in the clinical trial of Vioxx suffered heart attacks while participating in the trial while only one participant had a heart attack while taking the generic alternative naproxen. Most worryingly of all, this was technically a correct action to take due to the fact that the Annals of Internal Medicine has strict rules regarding statistical significance of findings."
Man these issues seem to run deep.
http://bigthink.com/neurobonkers/the-sta...of-science
"We then hear of a real case study concerning Merck’s Vioxx painkiller marketed in over eighty countries with a peak value of over two and a half billion. After a patient died of a heart attack it emerged in court proceedings that Merck had allegedly omitted from their research findings published in the Annals of Internal Medicine that five of the patients who participated in the clinical trial of Vioxx suffered heart attacks while participating in the trial while only one participant had a heart attack while taking the generic alternative naproxen. Most worryingly of all, this was technically a correct action to take due to the fact that the Annals of Internal Medicine has strict rules regarding statistical significance of findings."
Man these issues seem to run deep.